For example, the AMPA receptor agonist ampakine may help in correcting CNS dysfunction by increasing BDNF levels in animal models of Huntington’s disease and Rett syndrome, a rare autism spectrum disorder due to mutations in the DNA binding protein MeCP2 (methyl-CpG-binding protein 2) [74,75,76]. The gene discussed is MECP2; the disease is Huntington disease.