Intake of foods containing weak organic acids ameliorates (elevates) the lowered interstitial fluid pH in T2DM patients, rescuing T2DM patients from insulin resistance via elevation of insulin binding affinity to its receptor, and ameliorates (diminishes) the accumulation of amyloid-β by regulating activities of β-/γ-secretases and neprilysin. The gene discussed is INS; the disease is Insulin resistance.