TNF and rheumatoid arthritis: The role of SIRT4 in RA has not been studied, but SIRT4 can affect osteoarthritis through a variety of inflammatory factors, such as TNFα and IL-6, and the effect of SIRT4 on oxidative stress has also been proven the increased expression of SIRT4 can up-regulate SOD1, SOD2, and catalase [112].