In vitro: ⬇ cell viability, colony formation, SOD, CAT; ⬆ apoptosis (6 μM), Noxa levels (6 μM), p53, ROS, superoxide, IRE1α, PERK, BiP, GRP94, CHOP, cleaved caspase-3/8/9 and PARP;In vivo: ⬇ tumor growth; ⬆ Noxa levels. The gene discussed is EIF2AK3; the disease is neoplasm.