In vitro: ⬇ cell viability, TRAIL-induced colony formation; ⬆ apoptosis, DR5, PERK, eIF2α, ROS, CHOP, cleaved caspase-3, caspase-8 and PARPIn vivo: ⬇ tumor growth, ⬆ apoptosis, DR5, CHOP. Here, EIF2A is linked to neoplasm.