HAVCR2 and hepatocellular carcinoma: The T-cell-immunoglobulin-and-mucin-domain-containing protein 3 (Tim-3) was significantly upregulated in both tumor-infiltrating lrNK and cNK cells and suppressed their cytokine secretion and cytotoxic activity, thereby enhancing hepatocellular carcinoma growth by blocking natural killer cell function [69,85].