Degradation of Ikaros and Aiolos leads to suppression of interferon regulatory factor 4 (IRF4), a transcription factor critical for myeloma survival, as well as elevation of IL-2, an enhancer of natural killer cells, which supports attack on cancer cells and, thereby, inhibits tumorigenesis [62,68,71,77,78]. Here, IRF4 is linked to plasma cell myeloma.