All of the aforementioned studies conclusively demonstrated that the top 20 genes (FCER1G, AIF1.1, EIF4EBP2, MORF4L1, PRR13, CCNY.2, TUBB1, MAPKAPK3.1, IER3, PECAM1, CELF2.1, CORO1C.2, RTN4.1, XRCC5), which account for 70% of the disease, were either directly or indirectly associated to the development of AD. This evidence concerns the gene PRR13 and Alzheimer disease.