Ten years ago, a small pilot prospective trial demonstrated that daily treatment with a relatively low calcitriol dose (0.25 mcg) effectively negativized IAA and GAD antibodies within 0.6 (0.4–2.1) years in all 12 seropositive children (5 IAA, 6 GAD, 1 IAA+ GAD) aged 6.6 (1.5–13) years at inclusion [39]. This evidence concerns the gene GAD1 and generalized anxiety disorder.