LRG1 and appendicitis: An explanation of this is that saliva is a means of a timely detection of various diseases and conditions in children [9], as demonstrated by several studies, such as the one by Tintor et al. (2023) [10], in which the diagnostic accuracy as a novel biomarker for acute appendicitis of Leucine-rich α-2-glycoprotein 1 (LRG1) in saliva was investigated.