Single nucleotide polymorphisms of VEGFA, such as c.-2578C>A, c.+963C>T, c.-634C>G, c.-1154G>A and c.-460T>C, were associated with an increased risk of developing CHDs, especially for tetralogy of Fallot and ventricular septal defects [67,107,108,109]. Here, VEGFA is linked to Tetralogy of Fallot.