In this study, we sought to determine the diagnostic value of serum YKL-40 levels in term neonates with sepsis and to compare YKL-40 with other indices of inflammation, such as C-reactive protein (CRP), white blood cell count (WBC), absolute neutrophil count (ANC), and platelet count (PLT), currently used in clinical practice as sepsis biomarkers. This evidence concerns the gene CRP and Sepsis.