CD34 and melanoma: The latter immunoprofile is quite unspecific and the definite diagnosis of AFX should be established only after exclusion of other cutaneous spindle cell malignancies, by the use of a wider panel of immunohistochemical stains, such as Sox10 (for melanoma), CK5/6 and/or p63 (for spindle cell SCC), desmin (for tumors originating from the muscles), as well as CD34 or ERG (for angiosarcoma).