All patients with newly onset HGGs were positive for both [18F]-FET and [18F]-DPA-714 uptake, both TSPO and amino-acid PET were negative in one case, and the [18F]-FET result was positive and [18F]-DPA-714 negative in two cases (i.e., one grade III and one grade II oligodendroglioma). This evidence concerns the gene TSPO and oligodendroglioma.