EZH2 and thyroid cancer: In fact, it is known that EZH2, an enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), promotes EMT through epigenetic repression of tumor suppressor genes by inducing tri-methylation of histone H3K27 (H3K27me3), and we already demonstrated that PAR5 facilitates the E-cadherin expression by contrasting the effect of EZH2 in thyroid cancer cells.