The only independent predictors of lung fibrosis progression in Model 2 were high CCL18 serum levels (OR 1.009 [95% CI 1.003–1.015], p = 0.004) and positive antisynthetase autoantibodies (OR 5.075 [95% CI 1.120–22.999], p = 0.035). This evidence concerns the gene CCL18 and pulmonary fibrosis.