In Model 1, lower values of TLC (OR 0.944 [95% CI 0.900–0.991], p = 0.019), high CCL18 serum levels (OR 1.014 [95% CI 1.005–1.023, p = 0.001]) and the clinical phenotype (OR 4.949 [95% CI 1.516–16.103], p = 0.008) were independent predictors of PF-ILD. This evidence concerns the gene CCL18 and interstitial lung disease.