The RMI (Risk of Malignancy Index) Ovarian Cancer Risk Index, proposed in 1990 by Jacobs et al. [57], takes into account the sonomorphological characteristics of the tumour (U), the patient’s age (premenopausal—1 point, postmenopausal—3 pts) and the serum CA125 antigen concentration in IU/mL. Here, MUC16 is linked to ovarian cancer.