The two compounds were radiolabeled with 124I and 125I. The results indicated a higher brain uptake for [125I]I-OX265-F(ab’)2-Bapi after 4 h from the injection in TgF344-AD rats bearing human APP with the Swedish mutation (AβPP KM670/671NL) and human PSEN1 with exon nine deletion (PS1-ΔE9). The gene discussed is APP; the disease is Alzheimer disease.