GSK3B and Alzheimer disease: The cytoplasmic serine/threonine protein kinase Glycogen synthase kinase-3β (GSK-3β) was studied by Zhong and colleagues since it is involved in different biological processes, from glycogen metabolism, cell signaling and transport, cellular apoptosis, and neurogenesis, to the pathogenesis of AD, and it is well represented in human cortical regions, the locus coeruleus, the hippocampus, and the amygdala, while low concentrations are in the striatum.