TARDBP and Alzheimer disease: The researchers conducted an 11C-PK-11195 PET scan and an 18F-AV-1451 PET evaluation to detect areas with overexpression of TSPO and with aggregated non-amyloid-β pathological proteins, respectively, assuming the binding of 18F-AV-1451 in tauopathies and TDP-43-related disease, even if with lower affinity than in AD.