Tau protein has a pivotal role in the pathology of different diseases: Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), progressive supranuclear palsy (PSP), globular glial tauopathy (GGT), corticobasal degeneration (CBD), and Pick’s disease (PiD). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.