Carditis, joint complaints, subcutaneous lumps, and chorea are among the major criteria [9], while clinical signs such as fever and erythema marginatum, stomach pain, epistaxis, and pulmonary abnormalities and laboratory indicators of acute inflammation such as leukocytosis and a high erythrocyte sedimentation rate (ESR) or high C-reactive protein (CRP) make up the minor criteria [10]. Here, CRP is linked to inflammation of heart layer.