Carditis, joint complaints, subcutaneous lumps, and chorea are among the major criteria [9], while clinical signs such as fever and erythema marginatum, stomach pain, epistaxis, and pulmonary abnormalities and laboratory indicators of acute inflammation such as leukocytosis and a high erythrocyte sedimentation rate (ESR) or high C-reactive protein (CRP) make up the minor criteria [10]. The gene discussed is CRP; the disease is Increased total leukocyte count.