Moreover, other genes, such as SRD5A2, AR, DGKK, NR5A1, and WNT5A, involved in the steroidogenesis of androgens and in the functionality of hormones, were not identified as having a major risk in this case, but we do not exclude the involvement of endocrine disruptors in the hormone-dependent period of the development of the genital segments external as a possible cause in hypospadias. The gene discussed is AR; the disease is hypospadias.