Analyzing cleft lip and jaw independently by comparing the association of 13 major risk genes in this case with cleft lip and jaw reported in the literature and in the CleftGeneDB database, we can say that ACVR1, ADGRA2, BHMT2, BMPR1B, CDH1, EGF, F13A1, GSTP1, IRF6, MMP14, MYBPHL, PHC2, except CCDC8 can be involved in CLJ. This evidence concerns the gene IRF6 and cleft lip.