Table 1 presents the variant annotation genes known to be involved in CLJ and hypospadias in mammals with a high impact on the following overlapped genes: ACVR1, ADGRA2, BHMT2, BMPR1B, CCDC8, CDH1, EGF, F13A1, GSTP1, IRF6, MMP14, MYBPHL, and PHC2. The gene discussed is BHMT2; the disease is hypospadias.