For hypospadias, also the molecular mechanism is complex, many genes are implicated (e.g., AR, ATF3, ATF3, BMP4, BMP7, BNC2, CTGF, CYP1A1, CYR61, DGKK, EGESR1, ESR2, FGF8, FGFR2, GSTM1, GSTT1, HOXA4, HOXB6, HSD17B3, HSD3B2, MAMLD1, MID1, SF1, SRD5A2, WT1 [28,38,59,71,72]; CYP11a1, CYP17a1, HES3, HSD3b1, INSL1, SF1, STAR, STAT3 [73], DGKK, STS, ZEB1 [27], EFNB2 [40], or NR5A1 [74]), genes that physiologically are involved in the development of the male external genitalia in an indifferent stage or in the hormone-dependent stage. Here, HSD3B1 is linked to hypospadias.