There was no effect of temperature on basal plasma glucose (p = 0.73), insulin (p = 0.069), or NEFA (p = 0.56) concentrations, while the ratio of insulin to glucose was greater in HE animals (1.67 vs. 2.98 mU/mmol for TN and HE, respectively, SED 0.5827, p = 0.069). The gene discussed is INS; the disease is hereditary elliptocytosis.