Interestingly, our results showed that while HFHS diet-induced obesity induced marked weight gain, triglycerides accumulation, and the systemic impairment of glucose and insulin in the WT mice vs. those fed the NC diet, the AdipoQ-mCAT TG mice fed the HFHS diet were protected from incremental metabolic impairment compared to the WT mice. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.