In an article published by Wei et al., the authors suggested that an elevated expression of AKR1C3 could increase the resistance of cancer cells to ionizing radiation via the modulation of oxidative stress [57]: they explored the genetic alterations in non-radioresistant vs. resistant oesophageal cancer cells acquired due to long-term fractionated radiation, finding AKR1C3 more expressed in radioresistance-acquired cells. Here, AKR1C3 is linked to carcinoma of esophagus.