It acts as a potent antioxidant that inhibits the nuclear transcription factor kappa B (NF-κB) signaling pathway concomitantly with suppressing the expression of hypoxia-inducible factor 1 alpha (HIF-1α) and the vascular endothelial growth factor (VEGF), thus having pleiotropic effects on a variety of medical conditions related to inflammation, metabolic imbalance or cancer [89,90]. Here, HIF1A is linked to cancer.