SCFAs produced by fiber fermentation are able to influence the regulation of intestinal hormones such as gut trypsin peptide, glucagon-like peptide-1 (GLP-1), leptin, and peptide tyrosine–tyrosine (PYY) involved in energy balance and to maintain the integrity of the intestinal barrier by reducing the entry of substances that can generate metabolic inflammation responsible for metabolic disorders [68,69,70]. This evidence concerns the gene LEP and metabolic disease.