Although analgesic Capsaicin’s clinical use in neuropathic pain is related to the so-called “defunctionalization” of nociceptor fibers, explained through TRPV1-mediated actions [9], it has been demonstrated that Capsaicin exerts different TRPV1-independent pharmacological effects, such as anti-inflammatory [10], bacteriostatic [11], anti-obesity [12], and antioxidant effects [13]. The gene discussed is TRPV1; the disease is obesity due to melanocortin 4 receptor deficiency.