GCLC and cancer: Ferroptosis-related genes that were differentially downregulated in NAT10 KD cancer cells included glutamate–cysteine ligase catalytic subunit (GCLC), microtubules-associated protein 1 light chain 3α (MAP1LC3A), soluble carrier family 7 member 11 (SLC7A11) and soluble carrier family 39 member 8 (SLC39A8) (Figure 1A,B).