According to screening results of functional compounds including individual lignan and in vitro antioxidant and enzyme inhibitory activities, we selected the ‘Milyang 74’ cultivar with high lignan content and effective inhibitory capacity regarding acetylcholinesterase to evaluate anti-neurotoxicity in amyloid-β-induced SH-SY5Y cells, and produces an in vivo nootropic effect in scopolamine-induced memory impaired mice. The gene discussed is ACHE; the disease is memory impairment.