Serum levels of the redox-related genes Trx and manganese superoxide dismutase (MnSOD) are potential clinical biomarkers for predicting patient prognosis in hepatitis C virus-related hepatocellular carcinoma (HCC), as overall survival rate was lower in patients with high MnSOD levels and lower Trx levels [74,77]. This evidence concerns the gene SOD2 and hepatocellular carcinoma.