For example, pyruvate dehydrogenase kinase isoform 2 (PDK2) translocates from the mitochondria to the nucleus in different mouse and human xenograft tumor models of prostate cancer [129], and a heterogeneous expression and subcellular localization of the PDH complex in human prostate carcinoma LNCaP cells was also observed [130]. Here, PDK2 is linked to Familial prostate cancer.