Notwithstanding, an RSV-enriched diet prevented some of the cardiac alterations observed in fructose/STZ rats, such as the decrease in the MnSOD and CITED4 expression, prevented extracellular collagen accumulation, increasing IVS, LVPW, FS, and EF cardiac parameters, and improved the animals’ overall welfare by diminishing BW loss and polydipsia. The gene discussed is SOD2; the disease is Polydipsia.