On the other hand, a higher concentration of α-synuclein protein in different brain cell types, and the downregulation of α-synuclein in the brain regions, have been reported in some synucleinopathies; this might protect cells against oxidative stress [73] upon activating nuclear factor erythroide-2-related factor (Nrf2). This evidence concerns the gene SNCA and synucleinopathy.