PTS and hyperinsulinemic hypoglycemia, familial, 4: The treatment of PTPS deficiency can include a Phe-restricted diet, oral sapropterin dihydrochloride (BH4 supplementation) combined with neurotransmitter precursors (L-DOPA/decarboxylase inhibitor), 5-hydroxytryptophan, and folinic acid (Table 3).