APOD and neurodegenerative disease: APOD has been found to be the gene that is most upregulated with age [1], and its expression increases in various pathologies, particularly in several neurodegenerative diseases such as Parkinson and Alzheimer [1,2,3,4,5] but also during OS, starvation/growth arrest [6,7,8,9,10,11,12,13,14], cancer [9,15,16,17,18,19,20], hypothyroidism [21], and acute inflammation in response to cerebral viral infection [22] and LPS [7].