NFE2L2 and chronic kidney disease: Of these, the transcription levels of 38 common antioxidant genes regulated by NRF2 were all down-regulated in the kidneys of HN mice, which play an essential protective role in scavenging ROS in kidney diseases, such as diabetic nephropathy, autosomal dominant polycystic kidney disease (ADPKD), and CKD (Figure 2E) [30,31,32].