To investigate whether continuous light affected renal inflammation, we examined the levels of inflammatory cytokines, including pro-inflammatory factors Il-6 (Figure S5I, p < 0.05), Il-1β (Figure S5J, p < 0.001), Tnf-α (Figure S5K, p < 0.001) and monocyte chemoattractant protein-1 (Mcp-1, Figure S5L, p < 0.05) were markedly increased in LD-WF mice; meanwhile, the anti-inflammatory factor Il-4 was reduced (Figure S5M, p < 0.05). Here, IL4 is linked to inflammatory response.