Ravi et al. [28] found high levels of peroxynitrite and superoxide in left-heart failure induced rats, and showed that this mediated the downregulation of PTEN expression, a phosphatase-and-tensin homolog on chromosome 10 and a modulator of the phosphoinositide 3-kinase activity related to vascular remodeling. The gene discussed is PTEN; the disease is heart failure.