Hypertension is one of the complications of CVD, and the grape seed extract (GSEe) can reduce symptoms; the endothelin nitric oxide synthase (eNOS) expression of the GSEe group in human experiments increased by 45% compared to the vitro experiments, and the systolic and diastolic blood pressure were significantly reduced, compared with the placebo group [96,97]. Here, NOS3 is linked to hypertensive disorder.