For example, proanthocyanidins B2 can reduce the expression of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt); in this typical cancer pathway, proanthocyanidins B2 binds directly to specific points on protein kinase B (Akt) to reduce its expression, but does not have antitumor activity after mutations at specific points [126,127,128]. This evidence concerns the gene AKT1 and cancer.