ERBB2 and triple-negative breast carcinoma: Guo et al. showed upregulation of ICAM-1 in triple-negative breast cancers and used iron oxide particles coated with anti-ICAM-1 antibodies to image the tumors in a mouse xenograft model, achieving a signal comparable to previously published human epidermal growth factor receptor 2 (HER2)-targeting probes used for non- triple-negative breast cancer [226].