In GBM, it is well-known that the binding of Wnt ligands to FZD receptors activates the canonical β-catenin-dependent signaling pathway, which then promotes the expression of target genes through the formation of a large molecular complex together with TCF/LEF transcription factors and CREB Binding Protein (CBP)/p300 transcriptional co-factors [3,28,30,97,98,99] (Figure 1). Here, CREBBP is linked to glioblastoma.