TCF4 and glioblastoma: We and others previously suggested that certain HDAC inhibitors of the hydroxamate class, including suberoylanilide hydroxamic acid (SAHA, Vorinostat), could be indicated as Wnt signaling antagonists since they were able to deplete TCF4-dependent Wnt pathway activation in colon carcinoma cells [246] and to cause a general shutdown of the Wnt signaling cascade in GBM cells, finally impairing their proliferation and migration [248].