In normoxic conditions (i.e., environmental 20% oxygen), it has been demonstrated that canonical Wnt signaling activation enhances the expression of some EMT activators in GBM cells, including Zinc Finger E-Box Binding Homeobox 1 (ZEB1), Twist Family bHLH Transcription Factor 1 (TWIST1), and Snail Family Transcriptional Repressor 2 (SLUG), thus enhancing their migratory properties in vitro. The gene discussed is SNAI2; the disease is glioblastoma.