When CAF-derived exosomes cocultured with CRC cells were exposed to radiation, exosomes overexpressing miR-590-3p increased cell survival by altering the ratios of p-PI3K/PI3K and p-AKT/AKT, increasing CLCA4, and decreasing the expression of cleaved PARP, cleaved caspase-3, and γH2AX in cells [93]. Here, AKT1 is linked to colorectal carcinoma.