However, a follow-up analysis of the IMpassion130 trial suggested that a richer tumor immune microenvironment, as determined by intratumoral CD8 and stromal tumor-infiltrating lymphocyte positivity, was associated with PD-L1 immune cell-positive status and made the combination of atezolizumab with paclitaxel more efficacious [254]. The gene discussed is CD274; the disease is neoplasm.