TGFB1 and Hyperglycemia: However, in another study, streptozotocin-induced diabetic mice showed increased levels of miR-21, and lack of miR-21 was associated with accelerated glomerular injury and increased proteinuria, with a reduction in podocyte density, which leads to the conclusion that miR-21 ameliorates TGF-β1 and hyperglycaemia-induced glomerular injury through repression of pro-apoptotic signals [52].