Moreover, in a hyperglycaemia environment, many factors activate the transforming growth factor (TGF-β1), which activates downstream pathways that ultimately stimulate the secretion of the vascular endothelial growth factor (VEGF), increasing the glomerular permeability [14].Furthermore, VEGF, growth hormone, reactive oxygen species, and Angiotensin II can stimulate TGF-β, leading to an accumulation of mesangial extracellular matrix, podocyte hypertrophy, mitotic effects and changes in its morphology [15,16,17,18]. Here, VEGFA is linked to Hyperglycemia.