It has been shown that in B-cells of Chronic Lymphocytic Leukemia (CLL), mRNA related to Wnt elements is overexpressed, such as WNT3, WNT5B, WNT6, WNT10A, WNT14, WNT16 or FZD3 [43]. This evidence concerns the gene FZD3 and B-cell chronic lymphocytic leukemia.