FZD4 and acute myeloid leukemia: Other epigenetic mechanisms involved in tumor suppression are non-coding RNAs; the expression of MiR-212-5p reduces cell viability and inhibits proliferation in Kasumi-1 cells targeting FZD5 [64]; while MiR-150, which is related to FZD4, is downregulated in AML, ALL and CML, and its expression levels are normalized after complete remission [65].