PRDX4 and non-small cell lung carcinoma: Similarly, we have recently shown that Prx4 knockout FVB/N mice developed a reduced number and size of tumors compared to wildtype FVB/N mice in azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colorectal cancer and urethane-induced non-small cell lung cancer (NSCLC) [41,42].