Figure 2 represents some of the autoimmune and non-autoimmune cutaneous involvements in our patients. Of the immunologic parameters, IEI patients with skin disorders had significantly higher CD19+ cell percentages [12.0 (3.9–22.0)% vs. 6.9 (0.2–20.0)%; p = 0.002], IgA [19.5 (4.7–98.5) mg/dl vs. 10.0 (2.0–44.0) mg/dl; p = 0.004], IgG [605.5 (233.0–966.0) mg/dl vs. 240.0 (63.5–675.5) mg/dl; p < 0.001] and IgM levels [86.5 (35.0–186.5) mg/dl vs. 44.0 (14.0–144.5) mg/dl; p < 0.001] than those without skin involvements. The gene discussed is CD19; the disease is skin disorder.