The experiments showed that both of SP cells derived from hUCMSCs and hPMSCs could correct abnormal O-glycosylation in Tn+ CRC cells by increasing Cosmc and T-synthase protein, T-synthase, and C3GnT activity, and reducing the levels of Tn antigen expression on Tn+ cells. Here, C1GALT1C1 is linked to colorectal carcinoma.