From detecting the apoptosis of CRC cells before and after co-culture with SP-MSCs and HUVECs using Annexin V-PE/7-AAD, we found that the rates of apoptosis of HT-29-Tn+ and LS174T-Tn+ cells before cultured with SP-hPMSCs, SP-hUCMSCs, and HUVECs were lower than that in the corresponding HT-29-Tn− and LS174T-Tn− cells (Fig. 6a, b). This evidence concerns the gene ANXA5 and colorectal carcinoma.