Moreover, T-synthase and Cosmc protein in Tn+ and Tn− CRC cells after co-cultured with SP-hPMSCs and SP-hUCMSCs was increased, but has no changing in Tn+ and Tn− CRC cells after co-cultured with HUVECs (Fig. 7c and Additional file 1: Fig. S3). Here, C1GALT1C1 is linked to colorectal carcinoma.