In this study, we observed that T-synthase and C3GnT activity and Cosmc protein increased in CRC cells (LS174T-Tn−, LS174T-Tn+, HT-29-Tn−, and HT-29-Tn+cells) after co-cultured with SP-MSCs (SP-hUCMSCs and SP-hPMSCs) (Fig. 7) that appear along with abolishing or reducing of Tn antigen and generating new extended O-glycans (Figs. 3, 8, and 9). The gene discussed is C1GALT1C1; the disease is colorectal carcinoma.