Bone marrow-derived MSCs not only promote apoptosis and inhibit proliferation of glioma U251 cells via up-regulation of the IL-12 and IFN-γ levels and Bax/Bcl-2 expressions in tumor cells [50], but also restrict angiogenesis in ΔGli36 glioma xenograft via downregulation of the PDGF/PDGFR axis [51]. This evidence concerns the gene PDGFRB and central nervous system cancer.