SMYD3 and neoplasm: ﻿ Additionally, we observed a negative correlation between SMYD3 mRNA expression and methylation levels on particular probes, such as cg06985779 and cg15962031 (Additional file 1: Fig. S2A), with a concomitant reduction in DNA methylation levels of SMYD3 in tumor samples (Additional file 1: Fig. S2B).