SMYD3 complexed with RNA polymerase II and bound 5′-CCCTCC-3′ and 5′-GGAGGG-3′ motifs in the promoter region to transcriptionally activate downstream genes, like Nkx2.8 in colorectal and hepatocellular carcinomas [15]. The gene discussed is SMYD3; the disease is hepatocellular carcinoma.