Recently, our group reported that the Hsp70-Bim dimer recruits the oncogenic clients AKT, Raf-1, and eIF4E and mediates eIF2 signaling, the regulation of eIF4E and p70S6K signaling, and mTOR signaling pathway activation s to support chronic myeloid leukemia (CML) cell survival [12–14]. Here, BCL2L11 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.