Based on the results that, 1) DYX1C1 and DCDC2 are both dyslexia candidate genes, 2) they are both involved in neuronal migration and 3) they are both involved in ciliary processes, we asked whether there is a functional relationship between DYX1C1 and DCDC2. Here, we study a possible functional interaction between DYX1C1 and DCDC2 by using protein-protein interaction, subcellular localization and perturbation approaches in vitro and a genetic interaction model in vivo. The gene discussed is DCDC2; the disease is dyslexia.