LEP and myelodysplastic syndrome: A mean LEP promoter methylation above 51.03% at the time of diagnosis was able to stratify MDS patients with stable disease from patients with a progressive disease with a sensitivity of 60% and a specificity of 74% (positive predictive value = 63%, negative predictive value = 71%, and area under the curve (AUC) = 0.68, p = 0.019, Fig. 3B).