LEP and myelodysplastic syndrome: Next, we combined CCUS and lower-risk MDS patients (N = 65) and found that a mean LEP promoter methylation below 39.57% at the time of diagnosis was able to stratify survival from death with a sensitivity of 63% and a specificity of 67% (positive predictive value = 71%, negative predictive value = 58%, AUC = 0.64, p = 0.021, Additional file 2: Fig. S4).